Antifungals

  • Amphotericin

Amphotericin

  • Mechanism of Action: Anti-fungal; binds to ergosterol in fungal membranes and causes intracellular contents to leak out.
  • Indications: used for severe or disseminated fungal infections (invasive aspergillosis, cryptococcal meningitis, blastomycosis, coccidiomycosis)
  • Contraindications: allergy to class/drug
  • Dosage: Dosage varies significantly based on formulation. Generally, a single test dosage (1 mg in 20 mL of 5% dextrose) is infused over 20-30 minutes with close monitoring. If tolerated, then give a single daily dosage of 0.25mg/kg.
  • Half-life: Up to 14 days; depending on dosage
  • Adverse Reactions: Associated with significant renal toxicity. May also cause fever, chills, muscle rigor, and hypotension
  • Special Considerations: May cause hypokalemia and hypomagnesemia. Should be supplemented with potassium and magnesium. IV fluids help minimize nephrotoxicity.
Video Credit: Medicosis

*Deep Dive: Amphotericin B (Drugs.com)


Brandon Simpson, PA-S2
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